Kang Yell Choi Identification and Characterization of Small Molecules that Suppresses Growth of Cancers via Degrading both b-catenin and Ras
A research team led by Professors Kang Yell Choi in the Yonsei’s Department of Biotechnology has identified small molecules that inhibit growth of colorectal cancer (CRC) cells via degrading both b-catenin and Ras. The small molecules inhibiting the Wnt/b-catenin pathway were selected by screening of several small-molecule libraries. Among the 40 compounds initially identified by their inhibitory effects on the Wnt/b-catenin pathway reporter act..
Hosung Jung Location Matters: Local gene expression in neural circuits explained
College of Medicine Professor Hosung Jung and his team have uncovered the function of local mRNA translation in the formation and maintenance of neural circuits. Neurons make long-distance connections via their axons, which need a number of different proteins. The problem is that DNA, the blueprint to make proteins, resides in the neuronal cell body, which is often remote from the axon terminal. How proteins needed at the axon terminal are suppli..
Tea-Kyung Hong North Korea’s Nuclear Tests Could Trigger Volcanic Eruption in Mt. Baekdu
Currently, there are fears that North Korea could soon test a hydrogen bomb. Amidst these concerns, Yonsei Earth System Sciences Professor Hong Tae-Kyung and his team are studying how North Korea’s nuclear tests could affect seismic activities at Mount Baekdu. This is the first study to show that seismic waves following a nuclear test could possibly cause an earthquake and volcanic eruption at the mountain on the North Korean-Chinese border. Pro..
Hyun Woo Park TEAD Inhibition by p38 MAPK Reveals a Novel Tumor-suppressive Signaling Mechanism
This interesting study published in July 2017 in Nature Cell Biology identifying a novel tumor-suppressive cellular signaling mechanism has been conducted in collaboration between laboratories of Professor Hyun Woo Park (Yonsei University, Department of Biochemistry) and Kun-Liang Guan (UCSD, USA). Title: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation The Hippo pathway has gained tremendo..
개별 연구자 성과
- Hosung Jung
- Tea-Kyung Hong
- Kang Yell Choi