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Yonsei News

[YONSEI NEWS] Map of 'Gene Network' Developed

연세대학교 홍보팀 / news@yonsei.ac.kr
2011-05-31

95% of all human diseases are known to be "complex diseases" which are caused by interactions among multiple genes. This includes all diseases prevalent in modern society such as cancer, adult diabetes (type 2 diabetes), heart disease, and rheumatism. The development of a 'map of gene network' which shows the relationship between each human gene and another by a team of national researchers has provided new possibilities for curing these complex diseases. The research team of professor Lee In-suk (Yonsei University) and Doctor Marcotte (Texas State University) revealed on the 11th that they have built a human gene network model known as "HumanNet" (www.functionalnet.org/humannet). Until now, the biotechnology and medical world have commonly used the genome-wide association study (GWAS) to discover the genetic causes to various diseases such as cancer, diabetes, and heart disease. This method compares the genes of patients with a particular disease to the genes of normal people and then determines the genetic characteristics common only to the patient group. However, this method requires at least several thousand subjects and up to several tens of thousands to hundreds of thousands of subjects in order to discover a greater number of related genes. Professor Lee's team attempted to find the relationship among more than 16,000 genes, that is, to create the network among them into the form of a map, in order to ascertain the genetic causes of diseases. Professor Lee said, "By applying this gene network and GWAS together, genes related to the disease can be found more efficiently."