A Comprehensive Study of the Innate Immunity Reaction Inducing Signal Transduction Process Professor Kim Young-joon’s Research Team to Publish Paper in the “Annual Review of Biochemistry” A paper by Professors Kim Young-joon (Biochemistry, Director of the National Creative Research Center for Genome Regulation) and Lee Myeong-sup (research professor of the Genome Center) will be published in the 2007 issue (due for publication on July 7, 2007) of the “Annual Review of Biochemistry,” one of the most prestigious review journals in the field. The paper, titled “Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk,” deals with the signal transduction process, which induces innate immunity reactions crucial to our survival. When a virus enters our system, certain pattern-recognition receptors that exist in our body fluid, cell walls, and protoplasm recognize the virus and send out various signals internally within the cell, and externally as well. These signals cause a reaction that sets off our innate immune system. The receptors in our body fluid usually surround the virus to aid the phagocytosis that is mediated by the receptors in the cell walls, and the receptors in the cell walls and protoplasm send out signals that induce an inflammatory reaction. The review explains the signal transduction process involved when the signals sent out by the receptors activate transcription factors (such as NF-κB and IRF), and also gives current information regarding the interaction among the signals sent out by the receptors, an issue of current interest in the field of innate immunity. A Contribution to the Development of Cures for Immune Systems Disorders An innate immunity reaction that functions properly is crucial in fighting various viruses, and overactive immune reactions such as bacterial septicemia are harmful to a human body’s health. The comprehensive overview of the signal transduction process involved in the induction of innate immunity reactions is valuable not only for the purpose of providing knowledge for life science scholars, but also for the purpose of aiding medical scientists to develop new cures for immune systems disorders.