-Enable Personalized Stomach Cancer Treatment

 

 

A research team led by Yonsei College of Medicine Professor Jeong Jae-ho has successfully generated stomach cancer tumors and grafted them into immune-compromised mice. To duplicate the characteristics of tumors from actual patients, team members used the cutting-edge patient-derived xenograft (PDX) model. This tumor translation platform thus allows doctors to personalize

cancer treatments by first experimenting on the mice. The results of the research were published March 1 in Scientific Reports, a sister journal of Nature. The article’s title is “Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer.”

 

 

 

 

In the past, the PDX model has been used to treat brain tumors; however, it has only recently been employed to treat gastric cancer. This was the first time that the model, or “avatar mouse,” has been used in Korea. According to Professor Jeong: “In the future, by using the avatar mouse on patients with stomach cancer, customized cancer treatments, which respond to the cancer cell’s DNA changes, will be possible. This is very helpful.”