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| EDUCATION |
Ph.D., University of Texas at Austin, TX (12/2002)
Major: Molecular genetics & Microbiology
M.S., Western Illinois University, Macomb, IL (05/1996)
Major: Biology
B.S., Hanyang University, Seoul, Korea (02/1993)
Major: Biology
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| ACADEMIC EXPERIENCES |
Assistant Professor (03/2008 - present), Department of Biotechnology, Yonsei University, Seoul, Korea.
Probabilistic functional gene network for Arabidopsis, human, and Rice.
Research Associate (09/2006 - 02/2008), Post-doctoral fellow (01/2003 - 08/2006), Center for Systems and Synthetic Biology, University of Texas at Austin.
Biological data mining from various genomics and proteomics data, integration biological data into gene/protein network models, cellular system analysis by network topology, comparative network analysis (biological, social, internet), prediction of gene functions, phenotypic change prediction, probabilistic gene network modeling for yeast and C. elegans.
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| AWARDS |
Intelligent Systems for Molecular Biology (ISMB) Travel Fellowship Award, 2006
National Institute of General Medicine Science (NIGMS) Scholarship for Keystone Symposia of Systems Biology, 2006
Intelligent Systems for Molecular Biology (ISMB) Travel Fellowship Award, 2005
The L. Joe Berry Memorial Scholarship, University of Texas at Austin, 2001
David Bruton, Jr. Fellowship, University of Texas at Austin, 2000
Korean Honor Scholarship from Embassy of the Republic of Korea in the U.S., 1999
The Hal H. Ramsey, III Memorial Scholarship, University of Texas at Austin, 1999
Academic Achievement Scholarship, Hanyang University, 1986, 1991, 1992
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| PROFESSIONAL ACTIVITIES |
Journal Reviewing: Ad hoc reviewer for Genome Research, Genome Biology, and BioTechniques.
Long-term sponsored participant, Institute of Pure and Applied Mathematics (IPAM) Special Semester on “Proteomics: Sequence, Structure, Function”, University of California at Los Angelis, Spring 2004
Sponsored participant, Institute of Pure and Applied Mathematics (IPAM) short program “Sequence Analysis Toward System Biology”, University of California at Los Angelis, Jan 2006
Sponsored participant, Institute of Pure and Applied Mathematics (IPAM) short program “System Biology and Molecular Modeling”, University of California at Los Angelis, May 2006
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| RESEARCH INTERESTS |
Biological data mining
Biological network modeling
Systems Biology
Systems Gentics
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| SELECTED PUBLICATIONS |
1. Insuk Lee, Ben Lehner, Catriona Crombie, Wendy Wong, Andrew G. Fraser, Edward M. Marcotte. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nature Genetics 40:181-188 (2008), *Featured at Cover.
2. Kris McGary, Insuk Lee, Edward M. Marcotte. Broad network-based predictability of S. cerevisiae gene loss-of-function phenotypes. Genome Biology 8:R258 (2007)
3. Insuk Lee, Zhihua Li, and Edward M. Marcotte. An improved bias-reduced probabilistic functional gene network of baker’s yeast Saccharomyces cerevisiae. PLOS One 2:e988 (2007)
4. G. Traver Hart, Insuk Lee, Edward Marcotte. A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. BMC Bioinformatic 8:236 (2007)
5. Insuk Lee, Shailesh V. Date, Alex T. Adai, Edward Marcotte. A Probabilistic functional network of yeast genes. Science 306:1555-1558, (2004)
6. Bork, P., Jensen, L.J., Von Mering, C., Ramani, A.K., Lee I, Marcotte, E.M. Protein interaction networks from yeast to human. Curr. Opin. Struct. Biol. 14:292-9, (2004), *All authors contributed equally.
7. Insuk Lee and Rasika Harshey. Patterns of Sequence conservation at termini of LTR retrotransposons and DNA transposons in the human genome: Lessons from phage Mu. Nucleic Acids Res. 31:4531-4540, (2003)
8. Insuk Lee and Rasika Harshey. The conserved CA/TG motif at Mu termini: T specifies stable transpososome assembly. J. Mol. Biol. 330:261-275, (2003)
9. Insuk Lee and Rasika Harshey. Importance of the conserved CA dinucleotide at Mu termini. J. Mol. Biol. 314:433-444, (2001)
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