Koo, Hyeon Sook
Ph.D. (Yale University, 1987), Genome Instability Research Lab
kooh@yonsei.ac.kr 02-2123-2701
연세대학교 생명시스템대학 생화학과 (연세과학원 S409 호)
B.S., Dept. of Chemical Education, Seoul National University, 1978

M.S., Dept. of Chemistry, Korea Advanced Institute of Science & Technology, 1980

Ph. D., Dept. of Chemistry, Yale University, 1987 (Supervisor: Dr. Donald M. Crothers)
1980-1982: Researcher, Dept. of Radioisotopes, Korea Advanced Energy Research Institute

1987-1991: Postdoctoral fellow, Dept. of Biological Chemistry, Johns Hopkins University School of Medicine (Supervisor: Dr. Leroy F. Liu at New Jersey-Robert Wood Medical School)

1991-1995: Assistant Professor, Dept. of Biochemistry, College of Science, Yonsei University

1996-2000, Associate Professor, Dept. of Biochemistry, College of Science, Yonsei University

2001-present, Professor, Dept. of Biochemistry, College of Science, Yonsei University
1. Roles of the C. elegans RecQ DNA helicase (Werner syndrome protein) in the DNA damage checkpoint

2. Fanconi anemia pathway for DNA crosslink repair in C. elegans

3. Molecular action of Deleted In Cancer I (DICE-1) gene in the biogenesis of mitohondria
1. Jeong, Y.S., Kang, Y.l., Lim, K.H., Lee, M.H., Lee, J. & Koo, H.-S. (2003) Deficiency of Caenorhabditis elegans RecQ5 homologue reduces life span and increases sensitivity to ionizing radiation. DNA Repair 2, 1309-1319.

2. Lee, M.H., Han, S.M., Han, J.W., Kim, Y.M., Ahnn, J. & Koo, H.-S. (2003) C. elegans dna-2 is involved in DNA repair and is essential for germ-line development. FEBS Letters 555, 250-256.

3. Lee, S.-J., Yook, J.-S., Han, S.M. & Koo, H.-S. (2004) A Werner syndrome protein homologue affects C. elegans development, growth rate, life span, and sensitivity to DNA damage by acting at a DNA damage checkpoint. Development 131, 2565-2575.

4. Han, S.M., Lee, T.H., Mun, J.Y., Kim, M.J., Kritikou, E. Lee, S.-J., Han, S.S. Hengartner. M.O. & Koo, H.-S. (2006) Deleted-In-Cancer-1 (DICE-1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans. Development 133, 3597-3606.

5. Lee, K.Y., Yang, I., Park, J.-E., Baek, O.-R., Chung, K.Y. & Koo, H.-S.(2007) Developmental stage- and DNA damage-specific functions of C. elegans FANCD2. Biochem. Biophys. Res. Comm. 352,479-485.

6. Lee, H., Cho, J.S. Lambacher, N., Lee, J., Lee, S.-J., Lee, T.H., Gartner, A. & Koo, H.-S. (2008) The C. elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and required for resistance to oxidative stress and for normal motility and foraging behavior. J. Biol. Chem.283, 14988-14993.